Current Pharmacological and Emerging Non-pharmacological Treatments in Slowing the Progression of Mild Cognitive Impairment: A Literature Review

Introduction: MCI is considered as a prodromal stage between normal cognitive aging and dementia given its potential to develop into various forms of dementia, most notably Alzheimer’s disease (AD). This translates need for effective pharmacological non-pharmacological treatments prevent the progression subsequently slowing AD onset. review aims discuss effectiveness interventions in progression. Methods: A literature search was conducted using PubMed database randomized controlled trials (RCTs) examining with individuals MCI. Keywords included “mild impairment”, “drug”, “treatment”, “randomized trials”. Articles were evaluated on criteria relevant review’s purpose. Results: Studies different demonstrated promising results dementia. Acetylcholinesterase inhibitors (AChEIs) display favourable multiple assessments when compared placebo. Non-pharmacological interventions, such diet supplementation or exercise, also have improving performance multitude domains. Discussion: In RCTs, AChEIs displayed alleviating impairment associated MCI, but only temporarily some adverse effects. Given difficulty determining clear use additional research needed. without risk drug Literature regarding multimodal approaches combining both novel area research, these studies suggested positive additive Conclusion: Pharmacological results. More are needed determine which treatment plans, whether pharmacological, non-pharmacological, combination two, will prove be